Candesartan Mediated Amelioration of Cisplatin-Induced Testicular Damage Is Associated with Alterations in Expression Patterns of Nephrin and Podocin

Figure 1

Weights of testes, epididymal sperm concentrations, and percentages of sperm motilities and abnormalities following treatment with cisplatin and/or candesartan. Group 1 (), intraperitoneal (IP) injection of 2 mL isotonic saline; Group 2 (), IP injection of 2 mL isotonic saline and oral administration of candesartan 5 mg/kg/day; Group 3 (), IP injection of 4 mg/kg cisplatin; Group 4 (), IP injection of 4 mg/kg cisplatin and oral administration of candesartan 5 mg/kg/day; Group 5 (), IP injection of 7 mg/kg cisplatin; and Group 6 (), IP injection of 7 mg/kg cisplatin and oral administration of candesartan 5 mg/kg/day. Each column represents the mean value with standard deviation. ^†, , and differ from Groups 1, 3, and 5, respectively ().