Intra-Amniotic LPS Induced Region-Specific Changes in Presynaptic Bouton Densities in the Ovine Fetal Brain

Figure 3

The results of the quantitative analysis of the presynaptic bouton density (1/μm²) in layers 2-3 and layers 5-6 of different cortical areas. (a) The mean density of presynaptic boutons in the motor cortex. LPS2D and LPS14D animals showed a significant decrease compared to control animals in both layers. (b) The mean density of presynaptic boutons in the entorhinal cortex. LPS2D animals had a significantly lower density in layers 2-3 compared to controls and LPS14D animals showing a trend. (c) The mean density of presynaptic boutons in the somatosensory cortex. LPS2D animals had a lower density in layers 2-3 compared to controls and LPS14D animals showing a trend. (d) The mean density of presynaptic boutons in the piriforme cortex. All data are expressed as mean + SEM. (; and ^#0.05 < ).

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