Vitamin K1 Exerts Antiproliferative Effects and Induces Apoptosis in Three Differently Graded Human Colon Cancer Cell Lines

Figure 2

Apoptotic response of Caco-2, HT-29, and SW480 cell lines to vitamin K1 (VK1) treatment. Effects of increasing concentrations of VK1 (10 μM, 50 μM, 100 μM, and 200 μM) on the Bax/Bcl-2 mRNA level in Caco-2 (a), HT-29 (b), and SW480 (c) cell lines after 24 h, 48 h, and 72 h of treatment. All data represent the result of three different experiments (mean ± SEM). For each time of treatment, data were analyzed by Kruskal-Wallis analysis of variance and Dunn’s multiple comparison test. ^* compared to control cells.

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