Prokineticin 2 Upregulation in the Peripheral Nervous System Has a Major Role in Triggering and Maintaining Neuropathic Pain in the Chronic Constriction Injury Model

Figure 12

Evans Blue extravasation was measured at 3 dpi in injured and contralateral sciatic nerves. A significant increase in Evans Blue accumulation was evident in the injured nerve. The level of Evans Blue in the contralateral nerve was not significantly different from the level found in sham animals. Evans blue extravasation in the sciatic nerves of mice treated with PC1 (150 μg Kg⁻¹, twice/day, at 1 and 2 dpi) did not differ from sham mice. Data are expressed as mean ± SEM of 4-5 animals. One-way ANOVA was used for statistical evaluation, followed by Tukey test for multiple comparisons: ^*** CCI-saline versus sham mice; ^°°° CCI-PC1 versus CCI-saline mice.