Prokineticin 2 Upregulation in the Peripheral Nervous System Has a Major Role in Triggering and Maintaining Neuropathic Pain in the Chronic Constriction Injury Model

Figure 2

Antihyperalgesic effect of PC7. A single bolus s.c. injection of PC7 (5, 15, and 45 μg kg⁻¹) on day 3 after CCI dose-dependently reverted the established CCI-induced thermal hyperalgesia (a) and mechanical allodynia (b). The highest dose of PC7 (45 μg kg⁻¹) abolished hyperalgesia for about 3 h. Repeated systemic injections of PC7 (45 μg kg⁻¹, twice a day) from 3 to 7 dpi significantly reduced the CCI-induced thermal hyperalgesia (c) and mechanical allodynia (d) for all the observation period. Data represent means ± SEM of 5 mice. Two-way ANOVA was used for statistical evaluation, followed by Bonferroni’s test. ^°; ^°°; ^°°° CCI-PC7 versus CCI-saline mice.

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