Prokineticin 2 Upregulation in the Peripheral Nervous System Has a Major Role in Triggering and Maintaining Neuropathic Pain in the Chronic Constriction Injury Model

Table 1

Sciatic nerve cytokine levels ten days after CCI and after seven-day PC-1 treatment.

Cytokine; pg/mg protein	Sham	CCI-Saline	CCI-PC1
TNF	0	6.4 ± 3.1	0.97 ± 1.33^°
IL-1	64.26 ± 13.59	557.7 ± 121^**	222.5 ± 110.31^°
IL-6	4.92 ± 3.37	13.35 ± 6.15^*	4.30 ± 2.88^°
IL-17	0.97 ± 0.13	13.9 ± 1^*	3.1 ± 1.8^°
IL-10	556.8 ± 50.35	326.8 ± 8.99^*	867.3 ± 95.2^°°°

Values are means ± SD of 5 nerves.
; CCI-Saline versus Sham; , CCI-PC1 versus CCI-Saline.