Mineral and Skeletal Homeostasis Influence the Manner of Bone Loss in Metabolic Osteoporosis due to Calcium-Deprived Diet in Different Sites of Rat Vertebra and Femur

Figure 4

Fluorescence microscope micrographs showing a portion of transverse sections of the femoral mid-diaphysis. Note in sharp-edge-shaped sections the new bone deposition mostly located at the periosteal surface (arrows) and bone resorption at the endosteal surface (arrow heads). Group 2: control, normal diet; Group 3: calcium-deprived diet for 4 weeks; Group 4: calcium-deprived diet, plus concomitant administration of PTH (1-34) 40 μg/kg/day, for 4 weeks. Scale bar: 500 μm.