Gold Nanoparticles Promote Oxidant-Mediated Activation of NF-κB and 53BP1 Recruitment-Based Adaptive Response in Human Astrocytes

Figure 4

The effect of nanogold on micronuclei production (a) and 53BP1 recruitment (b). Human astrocytes were treated with  AuNPs/mL for 96 h. (a) The cytokinesis-block micronucleus (CBMN) assay. The bars indicate the SD, , , and compared with control (ANOVA and Dunnett’s a posteriori test). (b) 53BP1 foci were revealed using 53BP1 immunostaining. Cells with 0, 1, 2, 3, and more than 3 53BP1 foci were scored [%].

(a)

(b)