Modified Weekly Cisplatin-Based Chemotherapy Is Acceptable in Postoperative Concurrent Chemoradiotherapy for Locally Advanced Head and Neck Cancer

Table 4

Univariate and multivariate Cox regression analysis for the prognostic factors of overall survival.

	Univariate		Multivariate
	value	HR (95% CI)	value	HR (95% CI)
Age (years) ≥65	0.269
Male	0.761
Oropharynx	0.014	0.391 (0.185–0.829)	0.000	0.261 (0.116–0.586)
Extracapsular spread	0.012	2.443 (1.219–4.895)	0.007	2.709 (1.312–5.592)
Pathologic staging
pT > 2	0.894
pN > 1	0.472
p16^INK4A	0.583
Regional lymph node involvement	0.501
Resection margin status	0.891
Tumor emboli	0.476
Perineural invasion	0.611
Lymphovascular invasion	0.892
Total radiation dose ≥60 Gy	0.012	0.285 (0.107–0.761)	0.007	0.241 (0.086–0.679)
Weekly chemotherapy ≥7 cycle	0.152

HR: hazard ratio; CI: confidence interval.