Modified Weekly Cisplatin-Based Chemotherapy Is Acceptable in Postoperative Concurrent Chemoradiotherapy for Locally Advanced Head and Neck Cancer

Table 5

Main trials on adjuvant treatments comparing chemoradiotherapy with radiotherapy alone after primary surgery.

Author (year)	Patients	Compared arm	Median follow-up (months)	Outcome
Bachaud et al. 1996^# [10]	83^#	CP + RT vs. RT alone^#	60.0^#	2 y DFS rate, 68% vs. 44% ()^#
				2 y OS rate, 72% vs. 46% ()^#
Salama et al. 2007 [11]	114	Mito + Bleo + RT vs. RT alone	32.2	2 y DFS rate, 76% vs. 60% ()
				2 y OS rate, 74% vs. 64% ()
Cooper et al. 2004 [1]	459	CP + RT vs. RT alone	45.9	2 y DFS rate, 54% v. 45% ()
				2 y OS rate, 64% vs. 57% ()
Bernier et al. 2004 [2]	334	CP + RT vs. RT alone	60.0	5 y PFS rate, 47% vs. 36% ()
				5 y OS rate, 53% vs. 40% ()
Current study	126	CP + uracil-Tegafur + RT	30.0	2 y DFS rate, 70.9%
				2 y OS rate, 79.5%

Mito: mitomycin C; Bleo: bleomycin; RT: radiotherapy; CP: cisplatin; LRC: locoregional control; DFS: disease-free survival; OS: overall survival.