Lutein Has a Protective Effect on Hepatotoxicity Induced by Arsenic via Nrf2 Signaling

Figure 1

Morphological changes in mouse liver after arsenic trioxide (ATO) and/or lutein (LU). Control group showed normal structure of hepatic cord, hepatic sinusoid, and hepatocyte. The basic performance of the hepatocyte poisoning could be found in ATO treatment group, such as dim boundary of hepatocyte, dismissed cell membrane, cytoplasm disintegrating pieces, and the accumulation of lipid droplets intracytoplasm; meanwhile, the specific hepatocyte balloon degeneration performance can be observed. At the same time, inflammatory cells infiltration scattered in the liver tissue. AOT + LU group displayed fatty degeneration of hepatocytes and congestion but not observed balloon degeneration and hepatocyte disintegration. LU treatment group showed normal structure of liver cells as control group (400x magnification).

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