Lutein Has a Protective Effect on Hepatotoxicity Induced by Arsenic via Nrf2 Signaling

Figure 3

(a) Western blot analysis protein levels of treatment of arsenic trioxide (ATO) and/or lutein (LU). Nrf2 (molecular weight 57 kDa), Nqo1 (molecular weight 31 kDa), Ho-1 (molecular weight 32 kDa), and Gst (molecular weight 26 kDa) protein expression was measured in the livers of mice treated with arsenic trioxide (ATO) and/or lutein (LU) by western blot. (b) Quantitative protein analysis of treatment of arsenic trioxide (ATO) and/or lutein (LU). Nrf2, Nqo1, Ho-1, and Gst protein expression levels were measured. axis represents protein expression of test protein relative to β-actin. Each bar represents the mean ± SD. The protein expression of Nrf2, Nqo1, Ho-1, and Gst of LU treat group was significantly higher than those of control group. The group treated with ATO + LU showed the most prominent protein expression of Nrf2 related genes. Significant differences relative to the control and arsenic trioxide (ATO) groups are indicated as follows: versus control group, ; # versus ATO group, .

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