Lutein Has a Protective Effect on Hepatotoxicity Induced by Arsenic via Nrf2 Signaling

Figure 4

Representative immunohistochemical slides. Immunohistochemical slides were stained for Nrf2, Nqo1, Ho-1, and Gst in liver tissues with arsenic trioxide (ATO) and/or lutein (LU) treatment (200x magnification). Nrf2 protein expression located in nucleus and cytoplasm treated with ATO + LU. Nqo1, Ho-1, and Gst protein expression located in cytoplasm, nucleus, or membrane treated with ATO + LU. The protein expression level of Nrf2, Nqo1, Ho-1, and Gst of ATO + LU group was higher than other groups.

(a)

(b)

(c)

(d)