Lutein Has a Protective Effect on Hepatotoxicity Induced by Arsenic via Nrf2 Signaling

Table 1

Effect of arsenic trioxide (ATO) and/or lutein (LU) administration on indices related to hepatotoxicity in mice.

	Control (NS)	ATO (4 mg/kg)	LU (40 mg/Kg)	ATO + LU (4 mg/kg + 40 mg/Kg)
Initial body weight (g)	19.41 ± 1.16	19.31 ± 1.69	21.12 ± 1.43	20.50 ± 1.59
Final body weight (g)	34.68 ± 2.03	34.82 ± 1.19^ac	25.83 ± 1.96	30.37 ± 1.91^ab
Body weight gain (g)	15.27 ± 2.65	15.52 ± 1.71	4.71 ± 2.68	9.88 ± 1.93
Liver weight (g)	1.38 ± 0.17	3.23 ± 0.15^ab	1.05 ± 0.07^a	1.16 ± 0.26^ab
Liver index (%)	3.99 ± 0.61	9.29 ± 0.47^b	4.1 ± 0.49^a	3.88 ± 0.96^b
AST (U/g prot)	22.01 ± 4.95	31.62 ± 7.28^b	17.77 ± 4.97^a	10.87 ± 4.94^ab
ALT (U/g prot)	78.34 ± 21.40	136.51 ± 29.31^b	68.84 ± 17.25^a	59.98 ± 17.08^b

Note: the results were described as mean ± SD ( = 10). ^aIndicating significant difference from control (NS) group at < 0.01; ^bindicating significant difference from the ATO group (4 mg/kg) at < 0.01; ^cindicating significant difference from the ATO + LU group (4 mg/kg + 40 mg/Kg) at < 0.01.