Lutein Has a Protective Effect on Hepatotoxicity Induced by Arsenic via Nrf2 Signaling

Table 2

Effect of lutein (LU) on malondialdehyde (MDA), glutathione (GSH), superoxide dismutase (SOD), and total antioxidative capacity (T-AOC) of arsenic trioxide- (ATO-) treated mice.

Experimental group	MDA; nmol/mg prot	GSH; μmol/g prot	SOD; U/g prot	T-AOC; U/g prot
Control (NS)	2.89 ± 0.45	0.61 ± 0.04	0.48 ± 0.18	37.19 ± 5.79
LU (40 mg/kg)	3.03 ± 0.46	0.77 ± 0.06	0.56 ± 0.17	46.57 ± 2.21^b
ATO (4 mg/kg)	4.73 ± 0.54^ac	0.50 ± 0.05^ac	0.54 ± 0.14^ac	27.28 ± 4.13^ac
ATO + LU (4 mg/kg + 40 mg/kg)	3.58 ± 0.33^ab	0.67 ± 0.02^ab	0.55 ± 0.17^ab	29.38 ± 3.20^ab

Note: the results were described as mean ± SD ( = 10). ^aIndicating significant difference from control (NS) group at < 0.01; ^bindicating significant difference from the ATO group (4 mg/kg) at < 0.01; ^cindicating significant difference from the ATO + LU group (4 mg/kg + 40 mg/Kg) at < 0.01.