Association between AKT1 Gene Polymorphism rs2498794 and Smoking-Related Traits with reference to Cancer Susceptibility
Table 5
Comparisons of genotype data between presence/absence of cancer history stratified by smoking-related phenotypes.
Genotype
Genotypic model
Dominant model
Recessive model
TT
TC
CC
OR (95% CI)a
OR (95% CI)a
Smoking history
Ever-smokers
Cancer
17
65
40
3.281788
0.19381
1.017 (0.659–1.570)
0.005743
0.93959
0.617 (0.349–1.090)
2.805891
0.09392
Control
79
175
126
Never-smokers
Cancer
16
50
25
1.234473
0.53943
1.299 (0.782–2.159)
1.022436
0.31194
0.966 (0.530–1.761)
0.012551
0.91080
Control
68
184
124
Smoking period (year)
Long (≥44)
Cancer
13
31
24
0.392140
0.82195
1.226 (0.635–2.365)
0.181513
0.67008
1.226 (0.635–2.365)
0.341154
0.55916
Control
43
86
62
Short (<44)
Cancer
4
34
16
5.917681
0.05188
1.226 (0.635–2.365)
0.369160
0.54346
0.338 (0.115–0.996)
4.191842
0.04062
Control
36
88
64
CPDb
High (>20)
Cancer
9
19
12
1.526609
0.46612
1.642 (0.743–3.630)
1.514011
0.21853
1.194 (0.484–2.946)
0.147578
0.70086
Control
18
36
38
Low (≤20)
Cancer
8
46
28
5.512995
0.06351
0.849 (0.504–1.428)
0.382380
0.53633
0.402 (0.184–0.880)
5.491155
0.01911†
Control
61
139
88
Brinkman (smoking) index
High (>700)
Cancer
12
33
24
1.322869
0.51611
0.961 (0.536–1.723)
0.017720
0.89410
0.671 (0.330–1.365)
1.223659
0.26864
Control
43
76
61
Low (≤700)
Cancer
5
32
16
3.103819
0.21184
1.130 (0.586–2.181)
0.133278
0.71506
0.469 (0.174–1.261)
2.341073
0.12600
Control
36
97
65
Odds ratio (95% confidence interval). bCigarettes smoked per day. Significant association between the minor T allele of the SNP and noncancer status (present or past illness) in the recessive model () in subjects whose smoking duration is short. †Significant association between the minor T allele of the SNP and noncancer status (present or past illness) in the recessive model () in subjects whose CPD rate is low.