Lack of Association between JAK3 Gene Polymorphisms and Cardiovascular Disease in Spanish Patients with Rheumatoid Arthritis
Table 1
Demographic characteristics of the RA patients.
Clinical features
% ()
Patients
2136
Main characteristics
Age at the time of disease onset (years, mean ± SD)
50.8 ± 14.8
Follow-up (years, mean ± SD)
11.6 ± 8.3
Percentage of women
75.2
Rheumatoid factor positive*
69.1 (1430/2071)
Anti-CCP antibodies positive
59.1 (1063/1799)
Shared epitope positive
62.6 (762/1217)
Erosions
55 (902/1640)
Extra-articular manifestations**
31.1 (511/1640)
Cardiovascular risk factors
Hypertension
38.5 (810/2102)
Diabetes mellitus
12.4 (261/2102)
Dyslipidemia
36.0 (757/2102)
Obesity
18.1 (381/2102)
Smoking habit
24.5 (517/2102)
Patients with cardiovascular events
17.9 (384/2136)
Ischemic heart disease
8.4 (180/2136)
Heart failure
5.9 (126/2136)
Cerebrovascular accident
5.2 (112/2136)
Peripheral arteriopathy
2.4 (52/2136)
RA: rheumatoid arthritis; : number of patients; SD: standard deviation; Anti-CCP antibodies: anti-cyclic citrullinated peptide antibodies. *At least two determinations were required for analysis of this result. **Extra-articular manifestations of the disease (if RA patients experienced at least one of the following manifestations: nodular disease, Felty’s syndrome, pulmonary fibrosis, rheumatoid vasculitis, or secondary Sjögren’s syndrome) [4].
