Lack of Association between JAK3 Gene Polymorphisms and Cardiovascular Disease in Spanish Patients with Rheumatoid Arthritis

Table 10

Association between presence/absence of carotid plaques and JAK3 polymorphisms in RF negative RA patients.

Subgroup	Presence of carotid plaques		Genotypes/alleles	(%)	Presence of carotid plaques		Genotypes/alleles	(%)		OR^*95% CI
RF negative	Yes	rs3212780	GG	57 (46.0)		rs3212780	GG	60 (57.7)	—	Ref.
			GA	55 (44.3)			GA	37 (35.6)	0.13	1.64 0.86–3.14
			AA	12 (9.7)			AA	7 (6.7)	0.58	1.39 0.4–4.40
			G	169 (68.1)			G	157 (75.5)	—	Ref.
			A	79 (31.9)			A	51 (24.5)	0.20	1.36 0.84–2.22
		rs3212752	TT	111 (90.2)		rs3212752	TT	91 (88.3)	—	Ref.
			TC	12 (9.8)			TC	12 (11.7)	0.45	0.69 0.26–1.80
			CC	—	No		CC	—	—	—
			T	234 (95.1)			T	194 (94.2)	—	Ref.
			C	12 (4.9)			C	12 (5.8)	0.46	0.71 0.28–1.79
		Haplotypes	GT	163 (66.3)		Haplotypes	GT	150 (72.8)	—	Ref.
			AT	71 (28.9)			AT	44 (21.4)	0.16	1.43 0.86–2.40
			AC	8 (3.3)			AC	7 (3.4)	0.71	0.79 0.23–2.66
			GC	4 (1.6)			GC	5 (2.4)	0.71	0.76 0.18–3.14

RF: rheumatoid factor; RA: rheumatoid arthritis; OR: odds ratio; CI: confidence interval.
Adjusted for potential confounder factors.