Lack of Association between JAK3 Gene Polymorphisms and Cardiovascular Disease in Spanish Patients with Rheumatoid Arthritis

Table 2

Differences in genotype and allele frequencies of JAK3 polymorphisms between RA patients with or without cardiovascular (CV) events.

SNP	1/2	Subgroup	Genotype, (%)				Allele test
			1/1	1/2	2/2	MAF		OR 95% CI^*
rs3212780	G/A	Without CV events	909 (52.51)	688 (39.75)	134 (7.74)	0.28
		With CV events	191 (50.26)	160 (42.11)	29 (7.63)	0.29	0.51	0.93 0.75–1.06
rs3212752	T/C	Without CV events	1547 (88.30)	203 (11.59)	2 (0.11)	0.06
		With CV events	349 (90.88)	34 (8.85)	1 (0.26)	0.05	0.35	0.81 0.52–1.26

RA: rheumatoid arthritis. CV: cardiovascular. SNP: single nucleotide polymorphisms. MAF: minor allele frequency. OR: odds ratio. CI: confidence interval.
^*Adjusted for sex, age at the time of ultrasonography study, follow-up time, and traditional CV risk factors (hypertension, diabetes mellitus, dyslipidemia, obesity, and smoking habit) by logistic regression.