Lack of Association between JAK3 Gene Polymorphisms and Cardiovascular Disease in Spanish Patients with Rheumatoid Arthritis

Table 3

Association between JAK3 polymorphisms and carotid intima-media thickness (cIMT) and presence/absence of carotid plaques in RA patients.

	Genotypes/alleles	cIMT mm		Presence versus absence of carotid plaques
		Mean ± SD		OR 95% CI^**
rs3212780	GG ()	0.73 ± 0.17		Ref.
	GA ()	0.73 ± 0.17		1.13 0.79–1.61	0.51
	AA ()	0.77 ± 0.22	0.38	1.54 0.80–2.96	0.20
	G ()	0.73 ± 0.17
	A ()	0.74 ± 0.19	0.56	1.19 0.91–1.56	0.50
rs3212752	TT ()	0.73 ± 0.18		Ref.
	TC ()	0.74 ± 0.17	0.17	0.61 0.35–1.05	0.15
	CC ()	—	—	—	—
	T ()	0.74 ± 0.17
	C ()	0.74 ± 0.17	0.17	0.62 0.37–1.06	0.15

RA: rheumatoid arthritis. cIMT: Carotid intima-media thickness. SD: standard deviation. OR: Odds Ratio. CI: confidence interval.
^*Adjusted for sex, age at the time of ultrasonography study, follow-up time, and traditional CV risk factors (hypertension, diabetes mellitus, dyslipidemia, obesity, and smoking habit) using analysis of covariance (ANCOVA).
^**Adjusted for sex, age at the time of ultrasonography study, follow-up time, and traditional CV risk factors (hypertension, diabetes mellitus, dyslipidemia, obesity, and smoking habit) by logistic regression.