Lack of Association between JAK3 Gene Polymorphisms and Cardiovascular Disease in Spanish Patients with Rheumatoid Arthritis

Table 5

Association between cIMT values and JAK3 polymorphisms in RA patients stratified according to anti-CCP status.

Subgroup		Genotypes/alleles	cIMT (mm)
			Mean ± SD
Anti-CCP positive	rs3212780	GG ()	0.73 ± 0.17	0.55
		GA ()	0.73 ± 0.18
		AA ()	0.77 ± 0.23
		G ()	0.73 ± 0.17	0.50
		A ()	0.74 ± 0.19
	rs3212752	TT ()	0.73 ± 0.17	0.25
		TC ()	0.77 ± 0.18
		CC ()	—
		T ()	0.73 ± 0.18	0.27
		C ()	0.77 ± 0.18
	Haplotypes	GT ()	0.73 ± 0.17	0.53
		AT ()	0.74 ± 0.19
		AC ()	0.73 ± 0.21
		GC ()	0.77 ± 0.17
Anti-CCP negative	rs3212780	GG ()	0.71 ± 0.16	0.78
		GA ()	0.73 ± 0.17
		AA ()	0.77 ± 0.19
		G ()	0.72 ± 0.16	0.53
		A ()	0.74 ± 0.17
	rs3212752	TT ()	0.72 ± 0.17	0.53
		TC ()	0.73 ± 0.15
		CC ()	—
		T ()	0.72 ± 0.17	0.54
		C ()	0.73 ± 0.15
	Haplotypes	GT ()	0.72 ± 0.16	0.79
		AT ()	0.75 ± 0.18
		AC ()	0.73 ± 0.17
		GC ()	0.73 ± 0.11

cIMT: carotid intima-media thickness; anti-CCP: anti-cyclic citrullinated peptide; RA: rheumatoid arthritis; SD: standard deviation.
Adjusted for potential confounder factors.