Lack of Association between JAK3 Gene Polymorphisms and Cardiovascular Disease in Spanish Patients with Rheumatoid Arthritis

Table 7

Association between presence/absence of carotid plaques and JAK3 polymorphisms in anti-CCP positive RA patients.

Subgroup	Presence of carotid plaques		Genotypes/alleles	(%)	Presence of carotid plaques		Genotypes/alleles	(%)		OR^*95% CI
Anti-CCP positive	Yes	rs3212780	GG	76 (57.1)		rs3212780	GG	60 (49.6)	—	Ref.
			GA	44 (33.1)			GA	53 (43.8)	0.07	0.57 0.14–1.03
			AA	13 (9.8)			AA	8 (6.6)	0.72	1.21 0.42–3.47
			G	196 (73.7)			G	173 (71.5)	—	Ref.
			A	70 (26.3)			A	69 (28.5)	0.42	0.83 0.53–1.29
		rs3212752	TT	118 (88.7)		rs3212752	TT	104 (85.9)	—	Ref.
			TC	15 (11.3)			TC	17 (14.0)	0.36	0.67 0.29–1.56
			CC	—	No		CC	—	—	—
			T	251 (94.4)			T	225 (93.0)	—	Ref.
			C	15 (5.6)			C	17 (7.0)	0.38	0.69 0.31–1.55
		Haplotypes	GT	188 (70.1)		Haplotypes	GT	164 (67.8)	—	Ref.
			AT	63 (23.7)			AT	61 (25.2)	0.59	0.88 0.55–1.40
			AC	7 (2.6)			AC	8 (3.3)	0.24	0.49 0.15–1.58
			GC	8 (3.0)			GC	9 (3.7)	0.81	0.88 0.29–2.59

Anti-CCP: anti-cyclic citrullinated peptide; RA: rheumatoid arthritis; OR: odds ratio; CI: confidence interval.
Adjusted for potential confounder factors.