Lack of Association between JAK3 Gene Polymorphisms and Cardiovascular Disease in Spanish Patients with Rheumatoid Arthritis

Table 9

Association between presence/absence of carotid plaques and JAK3 polymorphisms in RF positive RA patients.

Subgroup	Presence of carotid plaques		Genotypes/alleles	(%)	Presence of carotid plaques		Genotypes/alleles	(%)		OR^*95% CI
RF positive	Yes	rs3212780	GG	105 (57.1)		rs3212780	GG	86 (52.4)	—	Ref.
			GA	63 (34.2)			GA	68 (41.5)	0.08	0.64 0.39–1.05
			AA	16 (8.7)			AA	10 (6.1)	0.96	1.02 0.41–2.56
			G	273 (74.2)			G	240 (73.2)	—	Ref.
			A	95 (25.8)			A	88 (26.8)	0.30	0.82 0.56–1.19
		rs3212752	TT	170 (92.4)		rs3212752	TT	139 (84.8)	—	Ref.
			TC	14 (7.6)			TC	25 (15.2)	0.08	0.50 0.24–1.07
			CC	—	No		CC	—	—	—
			T	354 (96.2)			T	303 (92.4)	—	Ref
			C	14 (3.8)			C	25 (7.6)	0.09	0.52 0.25–1.10
		Haplotypes	GT	265 (72.0)		Haplotypes	GT	229 (69.8)	—	Ref.
			AT	89 (24.2)			AT	74 (22.6)	0.60	0.90 0.61–1.33
			AC	6 (1.6)			AC	14 (4.3)	0.06	0.33 0.11–1.10
			GC	8 (2.2)			GC	11 (3.4)	0.63	0.78 0.28–2.15

RF: rheumatoid factor; RA: rheumatoid arthritis; OR: odds ratio; CI: confidence interval.
Adjusted for potential confounder factors.