Review Article
Long Noncoding RNAs as New Architects in Cancer Epigenetics, Prognostic Biomarkers, and Potential Therapeutic Targets
Figure 1
Molecular functions of lncRNAs.
(a) Signal: lncRNAs affect expression of the downstream gene and regulate transcriptional activity or pathway |
(b) Decoy: lncRNAs titrate proteins away from chromatin, or they can function as decoy for miRNA target sites |
(c) Guide: lncRNAs can recruit chromatin modifying enzymes to target genes and function as guides |
(d) Scaffold: lncRNAs can bring together multiple proteins to form ribonucleoprotein complexes |