Tetrahydrocannabinol Induces Brain Mitochondrial Respiratory Chain Dysfunction and Increases Oxidative Stress: A Potential Mechanism Involved in Cannabis-Related Stroke

Figure 2

THC impaired complexes I, II, III, and IV activities of the brain mitochondrial respiratory chain. Effects of  M of THC (black graphs) on brain mitochondrial respiratory chain complexes activities as compared to control values (white graphs). reflects complexes I, III, and IV activities and is measured using ADP. reflects complexes II, III, and IV activities and is measured using succinate. reflects complex IV activity and is measured using tmpd and ascorbate as mitochondrial substrates. THC: tetrahydrocannabinol. Data are means ± SEM and .