Developments in Screening Tests and Strategies for Colorectal Cancer

Table 3

Sensitivity and specificity of Cologuard compared to FIT (from Imperiale et al. [43]).

Sensitivity
Lesion detected	DNA	FIT
CRC	92.3%	73.8%
Advanced precancerous	42.4%	23.8%
Specificity
Lesion type and colonoscopy result	DNA	FIT
Nonadvanced w/negative scope	86.6%	94.9%
Negative scope	89.8%	96.4%

Advanced precancerous lesions include “advanced adenomas (high-grade dysplasia or with ≥25% villous histologic features or measuring ≥1 cm in the greatest dimension) and sessile serrated polyps measuring 1 cm or more in diameter.”