Development of In Vitro-In Vivo Correlation/Relationship Modeling Approaches for Immediate Release Formulations Using Compartmental Dynamic Dissolution Data from “Golem”: A Novel Apparatus

Table 1

Dissolution method description.

	Stomach	Duodenum	Jejunum	Ileum
Starting volume (mL)	30 (gastric juice) + 200 (deionized water)	33	33	33
Residence/transit time (min)	30; linear emptying	10	60	90
pH	2.4 (at 37°C)	6.5	6.6	7.4
Pepsin (mg/mL)	1.3	—	—	—
Lipase activity (U/mL)	—	70	70	70
Bile salts (mM)	—	3	3	3