BioMed Research International

Review Article

The Roles of SNF2/SWI2 Nucleosome Remodeling Enzymes in Blood Cell Differentiation and Leukemia

Table 1

Aberrant expression of SNF2 enzymes and CRC subunits in AML.
 Upregulated in AMLDownregulated in AML
SNF2 enzymesCHD1
FC 1.9		 
CHD2
FC 4.9		 
 HELLS
FC 0.69
 SMARCAD1/Etl1
FC 0.48
 TTF2
FC 0.54
 HLTF
FC 0.6
SWI/SNF complex subunits ARID1A/BAF250a
FC 2.1		 
SMARCD1/BAF60A
FC 1.7		 
SMARCC2/BAF170
FC 2.5		 
 ARID1B/BAF250b
FC 0.6
 ACTL6A/BAF53A
FC 0.4
 SMARCE1/BAF57
FC 0.7
INO80 complex INO80D/FLJ20309
FC 1.5		 
The table shows CRC with significantly changed expression ( < 0.0001) in AML compared to its closest normal counterpart at Hema Explorer [115]. The AML cohort consist of 144 patients with the following subtypes: 39 patients with t(8:21), 38 patients with t(15:17), 29 patients with inv(16)/t(16;16), and 38 patients with t(11q23)/MLL. FC = fold change.