The Roles of SNF2/SWI2 Nucleosome Remodeling Enzymes in Blood Cell Differentiation and Leukemia
Table 3
ICGC data for the noncatalytic CRC subunits.
CRC complex subunits
Mutations in malignant lymphoma
Mutations in AML
Mutations in CLL
SWI/SNF complex:
SMARCA4/Brg1
15/44 (34%)
2/75 (2.7%)
—
SMARCA2/Brm
8/44 (18%)
3/75 (4.0%)
1/109 (0.92%)
ARID1A/BAF250a
8/44 (18%)
2/75 (2.7%)
2/109 (1.8%)
ARID1B/BAF250b
14/44 (32%)
1/75 (1.3%)
—
ARID2/BAF200
8/44 (18%)
—
—
BAF180/PBRM1
—
5/75 (6.7%)
—
SMARCC1/BAF155
5/44 (11%)
5/75 (6.7%)
—
SMARCC2/BAF170
—
—
—
SMARCD1/BAF60A
—
—
—
SMARCD2/BAF60B
2/44 (4.5%)
1/75 (1.3%)
—
SMARCD3/BAF60C
4/44 (9.1%)
—
—
ACTL6A/BAF53A
5/44 (11%)
—
—
ACTL6B/BAF53B
1/44 (2.3%)
—
—
SMARCB1/BAF47/hSNF5
2/44 (4.5%)
2/75 (2.7%)
—
BAF45A/PHF10
3/44 (6.8%)
—
—
DPF1/BAF45B
—
1/75 (1.3%)
—
DPF3/BAF45C
10/44 (23%)
5/75 (6.7%)
—
DPF2/BAF45D
—
1/75 (1.3%)
1/109 (0.92%)
SMARCE1/BAF57
3/44 (6.8%)
—
—
BRD7
2/44 (4.5%)
—
—
BRD9
—
1/75 (1.3%)
—
β-actin/ACTB
5/44 (11%)
—
—
INO80 complex:
INO80
7/44 (16%)
1/75 (1.3%)
—
β-actin/ACTB
5/44 (11%)
—
—
ACTL6A/BAF53A
1/44 (2.3%)
—
—
Arp5/ACTR5
1/44 (2.3%)
1/75 (1.3%)
—
Arp8/ACTR8
1/44 (2.3%)
3/75 (4.0%)
—
RUVBL1/TIP49A
3/44 (6.8%)
2/75 (2.7%)
—
RUVBL2/TIP49B
3/44 (6.8%)
2/75 (2.7%)
—
IES2/INO80B/PAPA-1
1/44 (2.3%)
2/75 (2.7%)
1/109 (0.92%)
IES6/INO80C/c18orf37
3/44 (6.8%)
3/75 (4.0%)
—
YY1
4/44 (9.1%)
—
—
UCH37/UCHL5
3/44 (6.8%)
—
—
NFRKB/INO80G
—
3/75 (4.0%)
—
MCRS1/MCRS2/MSP58/INO80Q
2/44 (4.5%)
—
—
TFPT/Amida/INO80F
ND
ND
ND
INO80D/FLJ20309
4/44 (9.1%)
1/75 (1.3%)
—
INO80E/CCDC95/FLJ90652
2/44 (4.5%)
1/75 (1.3%)
—
EP400 complex: See shared subunits and additional subunits below
EP400
3/44 (6.8%)
2/75 (2.7%)
—
BRD8
2/44 (4.5%)
2/75 (2.7%)
—
TRRAP
6/44 (14%)
3/75 (4.0%)
—
Tip60/KAT5
2/44 (4.5%)
—
—
MRG15
7/44 (16%)
4/75 (5.3%)
—
MRGX
—
2/75 (2.7%)
—
FLJ11730
1/44 (2.3%)
1/75 (1.3%)
—
MRGBP
2/44 (4.5%)
2/75 (2.7%)
—
EPC1
6/44 (14%)
1/75 (1.3%)
—
ING3
3/44 (6.8%)
1/75 (1.3%)
—
SRCAP complex:
SRCAP
2/44 (4.5%)
1/75 (1.3%)
—
RUVBL1/TIP49A
3/44 (6.8%)
2/75 (2.7%)
—
RUVBL2/TIP49B
3/44 (6.8%)
2/75 (2.7%)
ACTL6A/BAF53A
5/44 (11%)
—
—
ACTR6
ND
ND
ND
GAS41
2/44 (4.5%)
1/75 (1.3%)
—
DMAP1
1/44 (2.3%)
2/75 (2.7%)
—
YL-1
2/44 (4.5%)
1/75 (1.3%)
—
NuRD complex (Mi-2):
CHD4
5/44 (11%)
3/75 (4.0%)
—
CHD3
—
4/75 (5.3%)
—
MBD3
—
—
—
MTA1
3/44 (6.8%)
2/75 (2.7%)
1/109 (0.92%)
MTA2
1/44 (2.3%)
1/75 (1.3%)
MTA3
8/44 (18%)
—
—
HDAC1
3/44 (6.8%)
—
—
HDAC2
4/44 (9.1%)
3/75 (4.0%)
—
RBBP7/RbAp46
1/44 (2.3%)
1/75 (1.3%)
—
RBBP4/RbAp48
—
2/75 (2.7%)
—
p66-α/GATAD2A
5/44 (11%)
1/75 (1.3%)
—
p66-β/GATAD2B
7/44 (16%)
1/75 (1.3%)
—
NURF complex /SMARCA1 (SNF2L)
5/44 (11%)
—
—
BPTF
3/44 (6.8%)
1/75 (1.3%)
—
RBBP7/RbAp46
1/44 (2.3%)
1/75 (1.3%)
—
RBBP4/RbAp48
—
2/75 (2.7%)
—
CHRAC complex SMARCA5 (SNF2H)
1/44 (2.3%)
—
—
hACF1/WCRF180
4/44 (9.1%)
—
—
hCHRAC17/POLE3
1/44 (2.3%)
—
—
hCHRAC 15
—
—
—
The ICGC data portal (https://dcc.icgc.org/) was queried with 67 genes encoding CRC subunits (October 2014). The frequency and percentage of mutations in the patients are indicated for each gene. Shared CRC subunits are marked with an asterisk (). ND = not determined.