BioMed Research International

Review Article

The Roles of SNF2/SWI2 Nucleosome Remodeling Enzymes in Blood Cell Differentiation and Leukemia

Table 3

ICGC data for the noncatalytic CRC subunits.
CRC complex subunitsMutations in malignant lymphomaMutations in AMLMutations in CLL
SWI/SNF complex:    
SMARCA4/Brg115/44 (34%)2/75 (2.7%)—
SMARCA2/Brm8/44 (18%)3/75 (4.0%)1/109 (0.92%)
ARID1A/BAF250a8/44 (18%)2/75 (2.7%)2/109 (1.8%)
ARID1B/BAF250b14/44 (32%)1/75 (1.3%)—
ARID2/BAF2008/44 (18%)——
BAF180/PBRM1—5/75 (6.7%)—
SMARCC1/BAF1555/44 (11%)5/75 (6.7%)—
SMARCC2/BAF170———
SMARCD1/BAF60A———
SMARCD2/BAF60B2/44 (4.5%)1/75 (1.3%)—
SMARCD3/BAF60C4/44 (9.1%)——
ACTL6A/BAF53A5/44 (11%)——
ACTL6B/BAF53B1/44 (2.3%)——
SMARCB1/BAF47/hSNF52/44 (4.5%)2/75 (2.7%)—
BAF45A/PHF103/44 (6.8%)——
DPF1/BAF45B—1/75 (1.3%)—
DPF3/BAF45C10/44 (23%)5/75 (6.7%)—
DPF2/BAF45D—1/75 (1.3%)1/109 (0.92%)
SMARCE1/BAF573/44 (6.8%)——
BRD72/44 (4.5%)——
BRD9—1/75 (1.3%)—
β-actin/ACTB5/44 (11%)——
INO80 complex:    
INO807/44 (16%)1/75 (1.3%)—
β-actin/ACTB5/44 (11%)——
ACTL6A/BAF53A1/44 (2.3%)——
Arp5/ACTR51/44 (2.3%)1/75 (1.3%)—
Arp8/ACTR81/44 (2.3%)3/75 (4.0%)—
RUVBL1/TIP49A3/44 (6.8%)2/75 (2.7%)—
RUVBL2/TIP49B3/44 (6.8%)2/75 (2.7%)—
IES2/INO80B/PAPA-11/44 (2.3%)2/75 (2.7%)1/109 (0.92%)
IES6/INO80C/c18orf373/44 (6.8%)3/75 (4.0%)—
YY14/44 (9.1%)——
UCH37/UCHL53/44 (6.8%)——
NFRKB/INO80G—3/75 (4.0%)—
MCRS1/MCRS2/MSP58/INO80Q2/44 (4.5%)——
TFPT/Amida/INO80FNDNDND
INO80D/FLJ203094/44 (9.1%)1/75 (1.3%)—
INO80E/CCDC95/FLJ906522/44 (4.5%)1/75 (1.3%)—
EP400 complex: See shared subunits and additional subunits below   
EP4003/44 (6.8%)2/75 (2.7%)—
BRD82/44 (4.5%)2/75 (2.7%)—
TRRAP6/44 (14%)3/75 (4.0%)—
Tip60/KAT52/44 (4.5%)——
MRG157/44 (16%)4/75 (5.3%)—
MRGX—2/75 (2.7%)—
FLJ117301/44 (2.3%)1/75 (1.3%)—
MRGBP2/44 (4.5%)2/75 (2.7%)—
EPC16/44 (14%)1/75 (1.3%)—
ING33/44 (6.8%)1/75 (1.3%)—
SRCAP complex:   
SRCAP2/44 (4.5%)1/75 (1.3%)—
RUVBL1/TIP49A3/44 (6.8%)2/75 (2.7%)—
RUVBL2/TIP49B3/44 (6.8%)2/75 (2.7%) 
ACTL6A/BAF53A5/44 (11%)——
ACTR6NDNDND
GAS412/44 (4.5%)1/75 (1.3%)—
DMAP11/44 (2.3%)2/75 (2.7%)—
YL-12/44 (4.5%)1/75 (1.3%)—
NuRD complex (Mi-2):   
CHD45/44 (11%)3/75 (4.0%)—
CHD3—4/75 (5.3%)—
MBD3———
MTA13/44 (6.8%)2/75 (2.7%)1/109 (0.92%)
MTA21/44 (2.3%)1/75 (1.3%) 
MTA38/44 (18%)——
HDAC13/44 (6.8%)——
HDAC24/44 (9.1%)3/75 (4.0%)—
RBBP7/RbAp461/44 (2.3%)1/75 (1.3%)—
RBBP4/RbAp48—2/75 (2.7%)—
p66-α/GATAD2A5/44 (11%)1/75 (1.3%)—
p66-β/GATAD2B7/44 (16%)1/75 (1.3%)—
NURF complex
/SMARCA1 (SNF2L)		5/44 (11%)——
BPTF3/44 (6.8%)1/75 (1.3%)—
RBBP7/RbAp461/44 (2.3%)1/75 (1.3%)—
RBBP4/RbAp48—2/75 (2.7%)—
CHRAC complex
SMARCA5 (SNF2H)		1/44 (2.3%)——
hACF1/WCRF1804/44 (9.1%)——
hCHRAC17/POLE31/44 (2.3%)——
hCHRAC 15———
The ICGC data portal (https://dcc.icgc.org/) was queried with 67 genes encoding CRC subunits (October 2014). The frequency and percentage of mutations in the patients are indicated for each gene. Shared CRC subunits are marked with an asterisk (). ND = not determined.