Hypoxia-Inducible Factor 1 Is an Inductor of Transcription Factor Activating Protein 2 Epsilon Expression during Chondrogenic Differentiation

Figure 2

Analysis of human and murine AP-2ε promoter sequences for HRE motives. Schematic drawings of the human and murine AP-2ε promoter (−2999 to −1 bp). All numbers refer to the translation start. The transcription start is marked with an arrow. Putative hypoxia responsive elements (5′-NCGTG-3′) are depicted as black boxes (HRE). Further, the position of a 604 bp human AP-2ε promoter construct (AP-2prom604) which was generated for a previous study is given [15].