Bone Marrow Cells in Acute Lymphoblastic Leukemia Create a Proinflammatory Microenvironment Influencing Normal Hematopoietic Differentiation Fates

Figure 1

Bone marrow cells from childhood acute lymphoblastic leukemia produce proinflammatory cytokines and hematopoietic growth factors. ALL mononuclear cells from BM aspirates were cultured for 24 h, and supernatants were further collected and assayed for 28 cytokines, chemokines, and growth factors. Normalized production relative to normal bone marrow cells was tabulated.