The Need for Biomarkers in Diagnosis and Prognosis of Drug-Induced Liver Disease: Does Metabolomics Have Any Role?

Figure 1

Hepatotoxicity of APAP. APAP: acetaminophen; SULT: sulfotransferase; UGT: glucuronosyltransferase; CYPs: P450 cytochromes; APAP-S: APAP-sulfonate; APAP-G: APAP-glucuronide; NAPQI: N-acetyl-p-benzoquinone imine; GST: glutathione S-transferase; GSH: glutathione; ROS: reactive oxygen species.