Antioxidant, Hepatoprotective Potential and Chemical Profiling of Propolis Ethanolic Extract from Kashmir Himalaya Region Using UHPLC-DAD-QToF-MS

Figure 4

Effect of different doses of KPEt on RIF-INH induced COX-2 expression in rat liver. Representative photomicrographs (magnification ×40). Group I: liver sections of 0.9% normal saline treated rats. Group II: hepatic sections of only RIF-INH fed rats showing higher expression of COX-2 as brown patches. Group III: liver sections of RIF-INH and Silymarin treated group showing almost no expressions. Group IV: liver sections of RIF-INH and KPEt 200 mg/kg b.wt treated group showing moderate expressions. Group V: liver sections of RIF-INH and KPEt 400 mg/kg b.wt treated group showing mild expressions. Group VI: scoring data for COX-2 positive cells counted on ten different loci randomly selected on the slide. Values are expressed as , toxic versus normal, , extract treated groups versus toxic, , extract treated groups versus toxic, and , extract treated groups versus toxic; n.s, not significant.