Antidepressant-Like Effect of the Leaves of Pseudospondias microcarpa in Mice: Evidence for the Involvement of the Serotoninergic System, NMDA Receptor Complex, and Nitric Oxide Pathway

Figure 4

Effects of pCPA (300 mg kg⁻¹, i.p. for 3 consecutive days) pretreatment on the behavioural response of PME (100 mg kg⁻¹, p.o.), fluoxetine (10 mg kg⁻¹, p.o.), and desipramine (10 mg kg⁻¹, i.p.) in the tail suspension test. Data are presented as group mean ± SEM (). ; versus vehicle-treated animals (one-way ANOVA followed by Newman-Keuls’ test). Significant difference between treatments: ; (two-way ANOVA followed by Bonferroni’s test).