Antidepressant-Like Effect of the Leaves of Pseudospondias microcarpa in Mice: Evidence for the Involvement of the Serotoninergic System, NMDA Receptor Complex, and Nitric Oxide Pathway

Figure 6

Effect of pretreatment of mice with cyproheptadine (8 mg kg⁻¹, p.o., a 5-HT₂ receptor antagonist, panel (a)), prazosin (3 mg kg⁻¹, p.o., a selective -receptor antagonist, panel (b)), propranolol (3 mg kg⁻¹, p.o., β-receptor antagonist, panel (c)), and yohimbine (3 mg kg⁻¹, p.o., -receptor antagonist, panel (d)) on PME- (100 mg kg⁻¹, p.o.) induced reduction in immobility time in the TST. Each column represents the mean ± SEM (). as compared with the vehicle-treated control. as compared with the group pretreated with vehicle and PME.

(a)

(b)

(c)

(d)