Hematopoietic Stem and Progenitor Cells Can Be Enriched by Implanting Biomaterial into Spatium Intermusculare

Figure 2

The migrating cells (MCs) contained functional hematopoietic stem and progenitor cells (HSPCs). (a) Colony-forming unit (CFU) assay of MCs and bone marrow (BM) cells. The colonies were classified by morphologic criteria; representative colonies were shown. Burst-forming unit-erythroid: BFU-E, colony-forming-unit-macrophage: CFU-M, colony-forming-unit-granulocyte, macrophage: GFU-GM, and colony-forming-unit-granulocyte, erythroid, macrophage, megakaryocyte: CFU-GEMM. (b) The frequency of colonies was shown; values were normalized to the number of input cells. The bars represented mean ± SD (); versus BM. (c) The frequency of each colony type (BFU-E, GFU-GM, CFU-M, and CFU-GEMM) in MCs was shown; values were normalized to the number of input cells. The bars represented mean ± SD (); versus BM.

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