Cardioprotective Activity of Pongamia pinnata in Streptozotocin-Nicotinamide Induced Diabetic Rats
Table 1
Effect of PPSB-PEE treatment on electrocardiographic, hemodynamic changes and LV contractile function in rats.
Parameters
Nondiabetic
Diabetic control
PPSB-PEE (100 mg/kg)
ECG
Heart rate (BPM)
353.48 ± 15.12
257.95 ± 32.52##
338.88 ± 41.08*
QRS interval (ms)
23.12 ± 5.23
13.74 ± 2.03##
18.23 ± 3.45*
QT interval (ms)
67.26 ± 1.24
91.00 ± 2.87###
73.63 ± 2.02*
QTc interval (ms)
131.08 ± 2.45
194.91 ± 3.88#
152.44 ± 0.89*
Hemodynamic
SBP (mmHg)
124.31 ± 1.22
87.51 ± 3.54###
115.84 ± 1.08***
DBP (mmHg)
91.41 ± 1.44
67.72 ± 1.02###
78.65 ± 1.32***
EDP (mmHg)
14.91 ± 2.11
7.13 ± 1.02###
18.28 ± 4.27***
MABP (mmHg)
122.25 ± 4.32
79.92 ± 0.12##
98.65 ± 0.78
LV function
Max / (mmHg/s)
3921.93 ± 322.34
2619.29 ± 80.41##
3695.72 ± 287.95*
Min / (mmHg/s)
−2513.14 ± 457.65
−1694.52 ± 447.21#
−2143.29 ± 398.47
Contractility index
56.18 ± 5.65
37.75 ± 3.18###
43.52 ± 2.98***
Data are expressed as mean ± SEM () and analyzed by one-way ANOVA followed by post hoc Dunnett’s test. *;***; ns: nonsignificant compared with diabetic group; #; ##; ###; ns: nonsignificant compared with nondiabetic group.
