Prevention of Polyglycolic Acid-Induced Peritoneal Adhesions Using Alginate in a Rat Model

Table 7

(a) Microscopic changes in the five groups in Experiment 1. (b) Residual alginates of the three alginate groups in Experiment 1.

(a)

Common changes in all groups
PGA fibers decreased in size
PGA fibers turned into flakes
Each PGA fiber was covered by macrophages and collagen-like substrates
Specific changes in each group
Fibrin group	The three alginate groups
Inflammatory cells, mainly lymphocytes, accumulated (8/8 rats)	Residual alginate was seen in two forms
	(1) Island-formation by gathering of many macrophages ingesting alginate (IF)
Huge lymph follicles were found around PGA fibers (3/8 rats)	(2) “Pool” of alginate in the free state (PA)

Common changes included three steps in the five groups. Specific changes in the fibrin group included two steps and those in the three alginate groups included residual alginate in two different forms (IF and PA).

(b)

Experimental groups	IF	PA
SL group	Small amount	Large amount
WL group	Small amount	Moderate amount
NL group	Small amount	Small amount

IF: many macrophages were gathered in the form of an island, where they ingested the alginate.
PA: there was a “pool” of alginate in a free state.