Involvement of the Gut Chemosensory System in the Regulation of Colonic Anion Secretion

Figure 3

Schematic diagram of secretion stimulated by an odor tastant (thymol) in colonic epithelial cells. Activation of OR1G1 by luminal thymol increases . The elevated may modulate -activated basolateral channels, providing a driving force for the exit of . Activation of OR1G1 may also activate TRPA1 although it is still unclear whether ORs are linked to TRPA1.