NOD-Like Receptor Signaling in Cholesteatoma

Figure 3

Altered inflammatory gene regulation in cholesteatoma versus EAS via microarray analysis. Significant upregulation of the inflammatory-related genes IL1, cFlip, p65, and IRAK. Moreover, there was a significant upregulation of the pattern recognition receptor (PRR) NOD2, but no significant upregulation of NOD1, TLR2, or TLR4 and the adaptor protein RIPK2. Furthermore, the figure displays a downregulation of NGFR in cholesteatoma. Gene expression analysis was performed via microarray analysis.