mir-21 Overexpressing Mesenchymal Stem Cells Accelerate Fracture Healing in a Rat Closed Femur Fracture Model

Figure 3

mir-21-MSCs intervention accelerated endochondral ossification via histological analysis. (a) Representative sections stained with Safranin O indicated endochondral ossification partially accomplished in mir-21-MSCs intervention group. In contrast, lots of uncalcified chondrocytes which remained in fracture site implied delayed healing. (b) The result of HE staining showed that the continuity of bone had been recovered and bone remodeling was taking place vigorously in the mir-21-MSCs intervention group, while cracks still could be detected and bone remodeling was inconspicuous in control group.

(a)

(b)