A Kinetic-Model-Based Approach to Identify Malfunctioning Components in Signal Transduction Pathways from Artificial Clinical Data

Figure 6

The artificial clinical data generated by adding noise to the nuclear STAT3 dimer and SOCS3 profiles from the model simulation: (a) upregulation of each reaction rate, (b) downregulation of each reaction rate, (c) upregulation of each preexisting molecule, and (d) downregulation of each preexisting molecule.

(a)

(b)

(c)

(d)