A Kinetic-Model-Based Approach to Identify Malfunctioning Components in Signal Transduction Pathways from Artificial Clinical Data

Table 10

Rank of the possibility of preexisting molecules whose downregulation causes the abnormal profiles (magenta colored curve shown in Figure 9(d)). TNF-α/NF-κB pathway is used for this example.

Number	Molecule index
1	TRAF2	0.98	0.00062	0.34
2	RIP-1	0.97	0.00048	0.25
3	IKKn	0.93	0.00078	0.29
4	Free nuclear NF-κB	0.89	0.00095	0.35
5	Free cytoplasmic NF-κB	0.89	0.0013	0.45