Research Article

A Kinetic-Model-Based Approach to Identify Malfunctioning Components in Signal Transduction Pathways from Artificial Clinical Data

Table 2

The rank of the possibility of the reactions whose downregulation causes the abnormal profiles shown in Figure 6(b).

Rank Reaction index (STAT3N-STAT3N) (SOCS3)

1 44 0.98 0.98 0.98
2 43 0.77 0.97 0.0017
3 40 0.77 0.97 0.0017
4 47 0.46 0.015 0.88
5 46 0.42 0.014 0.94
6 36 0.29 0.27 0.34
7 41 0.29 0.0040 0.86
8 42 0.25 0.41 0.036
9 34 0.22 0.20 0.27
10 11 0.17 0.15 0.24