A Kinetic-Model-Based Approach to Identify Malfunctioning Components in Signal Transduction Pathways from Artificial Clinical Data

Table 5

The top five reactions whose upregulation may cause the abnormal profiles shown in Figure 9(a) (Rxn9 is IKK inactivation reaction caused by A20; Rxn33 is decomposition of TNF-αTNFR1 complex to free TNF-α and TNFR1; Rxn12 is IKKa, IKKn, and IKKi degradation; Rxn46 is composition of TNF-αTNFR1TRADDTRAF2RIP-1 and FADD to a complex; Rxn17 is IKKIκBαNF-κB decomposition with NF-κB releasing).

Number	Reaction index
1	9	0.99	0.0014	0.97
2	33	0.82	0.0015	1.0
3	12	0.69	0.00089	0.68
4	46	0.56	0.00032	0.24
5	17	0.38	0.0010	0.73