A Kinetic-Model-Based Approach to Identify Malfunctioning Components in Signal Transduction Pathways from Artificial Clinical Data

Table 6

Ranking of the possibility of the reactions whose downregulation causes the abnormal profiles shown in Figure 9(b) (Rxn16 is IKKaIκBα degradation; Rxn45 is release of IKK from IKKIκBαNF-κB complex; Rxn14 is IKKa and IκBα association; Rxn9 is IKK inactivation reaction caused by A20; and Rxn10 is IKK spontaneous inactivation).

Number	Reaction index
1	16	0.98	0.0051	3.8
2	45	0.61	0.0012	0.68
3	14	0.57	0.0012	0.55
4	9	0.50	0.0018	0.25
5	10	0.46	0.0016	0.25