The Ethanolic Extract of Taiwanofungus camphoratus (Antrodia camphorata) Induces Cell Cycle Arrest and Enhances Cytotoxicity of Cisplatin and Doxorubicin on Human Hepatocellular Carcinoma Cells

Table 3

Analysis of combination drug effects of TCEE with cisplatin or doxorubicin in Hep3B and HepJ5 cells. Combination drug index (CDI) was analyzed on cell viability data obtained from Figure 3 by using the CalcuSyn software. CDI < 1 indicated a synergistic effect, CDI = 1 indicated an additive effect, and CDI > 1 indicated an antagonistic effect.

		Combination drug index
		Hep3B	HepJ5
		Plus 0.2 mg/mL TCEE	Plus 0.5 mg/mL TCEE
Cisplatin (μM)	1	0.52	0.75
	2	0.59	0.77
	4	0.64	0.96
	6	0.61	1.08
	8	0.48	1.03
	10	0.47	0.88
	20	1.16	0.55
Doxorubicin (μM)	0.5	0.61	1.39
	1	0.77	1.04
	1.5	0.74	0.71
	2	0.38	0.79
	3	0.32	0.72
	4	0.58	0.58
	5	0.67	0.78