Single-Stranded DNA Aptamers against Pathogens and Toxins: Identification and Biosensing Applications

Table 3

Summary table of ssDNA MREs targeting viruses and virus proteins for therapeutic applications.

Virus	Target	SELEX method		Reference
HIV	Reverse transcriptase	Nitrocellulose filters	—	[126]
HIV	Reverse transcriptase	Sephadex columns	660 pM	[127]
HIV	Reverse transcriptase	Nitrocellulose filters	1 nM	[128]
HIV	Reverse transcriptase	Primer-free SELEX	82 nM	[129]
HIV	Integrase	Nitrocellulose filters	—	[130]
HIV	Integrase	—	—	[131]
HIV	Trans-activation-responsive RNA (TAR) element	Magnetic beads	20 nM	[132]
HIV	Trans-activation-responsive RNA (TAR) element	Magnetic beads	50 nM	[133]
HCV	NS5B RNA polymerase	Nitrocellulose filters	132 nM	[134]
HBV	Core protein	—	High affinity determined by dot blot	[135]
SARS coronavirus	Helicase	Magnetic beads	5 nM	[136]
Influenza A virus	Hemagglutinin from H3N2	Ni-NTA beads	—	[137]
Influenza A virus	Hemagglutinin from H5N1	Ni-NTA beads	High affinity determined by ELISA	[138]
Influenza A virus	Hemagglutinin from H3N2	Ni-NTA magnetic beads	7 nM	[139]
Influenza A virus	Hemagglutinin from H9N2	Nitrocellulose filters	High affinity determined by ELISA	[140]
Influenza A virus	Nonstructural protein 1	Glutathione agarose beads	18.91 ± 3.95 nM	[141]
Rabies virus	Rabies virus infected BHK-21 cells	Cell-SELEX	28 nM	[142]
HPV	HPV transformed HeLa cells	Cell-SELEX	1 nM	[143]
Vaccinia virus	Whole virus particle	One-step MonoLEX	High affinity determined by dot blot, SPR, and so forth	[144]