Preclinical Evaluation of the Immunomodulatory Properties of Cardiac Adipose Tissue Progenitor Cells Using Umbilical Cord Blood Mesenchymal Stem Cells: A Direct Comparative Study

Figure 4

Cytokine levels are specifically modulated by the number of cardiac ATDPCs or UCBMSCs seeded in the allostimulatory assay. Histograms represent detected levels of early stage (a) and late stage (b) cytokines in the supernatants from cocultures of increasing numbers of cardiac ATDPCs (white circles) or UCBMSCs (black squares) with T cells and allogeneic mature MDDCs (20 : 1 ratio). Data are expressed as mean ± SD from four independent experiments ( for UCBMSCs, cardiac ATDPCs, and responder T cells). Statistical differences, indicated as , , and , were only found for cardiac ATDPCs.

(a)  

(b)